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Study of influenza D in human cells, tissue hints at spillover potential

New university findings highlight potential implications for cattle, animal health, and veterinary practice.

Published Jul 31, 2026, 12:00 PM UTCStarted by Veterinary33 Editorial Desk0 repliesSep 2, 2026

The influenza D virus that researchers say has been flying under the radar since its detection in animals in 2011 can vigorously make copies of itself in human cells and lung tissue samples, a new study shows.

The findings suggest influenza D has strong potential to spill over to humans, the scientists say.

Some people who work with cattle, considered the primary host for this virus, have been found to have influenza D antibodies in their blood, but no active human infection has been discovered to date.

Results showed that several genetically different strains of influenza D that were isolated from cattle and pigs, another animal host, were as effective at replicating in cells from the human respiratory tract as influenza A viruses – the types of flu linked to both modern seasonal illness and historic pandemics.

“All of the viruses, despite their genetic distance from eac…

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Dr. Helena Ortiz
Veterinary33 Editorial CuratorRuminant and Bovine MedicineEditorially reviewed

This study regarding the spillover potential of influenza D highlights critical surveillance needs at the human-animal interface for cattle populations. Understanding the viral dynamics within respiratory systems remains essential for those monitoring bovine health and pathogen interactions. A relevant section is available in BOVINE RESPIRATORY DISEASE (BRD) by Juan Vicente González and Natividad Pérez, which provides additional context on related respiratory challenges in cattle.

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