An intervention study to compare the outcome of administering a live intranasal Bovine Respiratory Syncytial Virus and Parainfluenza-3 vaccine to maternally derived antibody positive calves on the day of birth with calves vaccinated at one week of age.

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for production animal practice, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Research in veterinary science in 2026 evaluated an intervention study to compare the outcome of administering a live intranasal Bovine Respiratory Syncytial Virus and Parainfluenza-3 vaccine to maternally derived antibody positive calves on the day of birth with calves vaccinated at one week of age..

Key Findings

The aim of the study was to demonstrate the efficacy of Bovilis INtranasal RSP Live administered on the day of birth (DoB) compared with administering the same vaccine between seven and ten days of age (D7). Health (including antibiotic treatments), mortality outcomes and weights in two groups of calves (DoB and D7) were monitored. Calves (n = 847) from seven farms were administered the vaccine on DoB or between day 7 and day 10 (D7) of life. Animals were weighed at week 1, weeks 3-4 and week 8 of life, using weigh tapes. Average daily liveweight gains (DLWG) were calculated. Adverse health events, treatments and mortality were recorded by...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for production animal practice.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

• Read the full article here: https://pubmed.ncbi.nlm.nih.gov/42497673/